About this project

The Collection of Immunolabeled Transparent Human Embryos and Fetuses is the most advanced molecular embryology tool. Building upon the pioneering ‘DISCO’ clearing methods developed for rodent embryos, we have shifted gears to another level, where direct knowledge of molecular and cellular ontogenesis may prove critical to improve Human pregnancy. Birth defects, of structural or functional origin, afflict more than 3% birth1, reaching 6-7% of live–born infants at their first anniversary2. Further, with a prevalence of one in 700 newborns presenting with craniofacial abnormalities3 – these conditions represent the most serious public healthcare burden. Our 3D data collection demonstrates that with thorough biochemical optimization, we can now detect any cell population of all developing systems during organogenesis of healthy and pathological Human embryos and fetuses. This open-access project welcomes implementation by researchers, clinicians and all experts who deal with ontogenetic processes.

This collection is the first Human Cell Atlas currently organized along six of the human organ systems. The ontogenic markers selected here span most morphogenetic processes, from proliferation to migration and terminal differentiation. We present here a selection of images and videoclips from a sortable and searchable database. New data and 3D tools will be regularly added.

Terms of use, Material Transfer Agreement Form, and Contact coordinates can be found on this Home page.

 

1 – CDC : https://www.cdc.gov/ncbddd/birthdefects/data.html

2– PCRM : http://www.pcrm.org/research/resch/reschethics/birth-defect-statistics

3 – WHO : http://www.who.int/genomics/publications/CFA%20Completed%20text.pdf

Most Viewed

GnRH cells in the head (GW6.5)

Lateral and oblique projections of the whole head of a GW6.5 human embryo immunolabeled for GnRH. Chains of GnRH neurons enter the brain and progress either dorsally or...

Latest videos

GnRH cells in the head (GW6.5)

Lateral and oblique projections of the whole head of a GW6.5 human embryo immunolabeled for GnRH. Chains of GnRH neurons enter the brain and progress either dorsally or...

Lymphatic cells in gut (GW14)

Blood and lymphatic cells share an embryological origin, and the development of both vascular systems are connected. In this movie, gut lymphatic progenitors (white) are...

Knee artery (GW11.5)

This movie travels around and into the knee or politeal artery (white) as it starts from the femoral artery and branches deep into the capsule.

Researcher Access

To access the entire collection of 3D data sets (about 1000 acquisitions corresponding to 1.5 million tiff images), you must download, fill and sign the attached Material Transfer Agreement (MTA).
Access to this database is currently restricted to Academic Scientists.
If you are not a scientist but would like to obtain some original 3D data sets please send an email to 3d.database.access@institut-vision.org

Researcher Access

Tranparent Human Embryo
Subscribe to Our Newsletter